克罗米萘对男性低促性腺素性功能减退症有效

纽约（名记者心理健康版）1月底四日报道：据出版在12月底出版的《不孕与后代》时代周刊的一项份文件表明克罗米酰对部份低促性腺素广泛性消退的男性高血压薄弱。来自伯明翰阿拉巴马大学的该份文件的第一原作者Scott J. Whitten博士在给予路透新闻机构采访问道：“原发性或获得性HH高血压在给予扰乱性相当大和更为昂贵的病人（例如针头促性腺激素类）前进行4个月底的克罗米酰试验性病人是薄弱的。”Whitten博士和上司研究者了克罗米酰对10名HH男性高血压（HH是避免男性后代的少见因素）到底有效。份文件称之为克罗米酰病人1年后，4名卡尔曼(氏)综合征高血压中只有一名高血压的卵子酸度增加而全垂体新功能消退症高血压的卵子不足症状均没有人获取优化。只不过，该份文件表明3名成年发病的原发性HH男性高血压经过3个月底克罗米酰的病人卵子酸度有了明显增加。目前为止该组高血压已有两名丧失了不孕能力。Whitten博士说道：“除非对克罗米酰病人没有人反应，我们就会因为副作用停顿对高血压使用该本品。”最后原作者总结说道：“因为情况下有限，对HH高血压促性腺激素类本品和克罗米酰的随机研究者难于进行，然而利用多前传的严格并不需要标准对高血压进行分级显然努力实质性检验克罗米酰丧失男性低不孕能力的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

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编辑： 张靖